Friday, 25 November 2011

Silent treatment creates a gem with 'The Artist' (AP)

LOS ANGELES ? "The Artist" is a dream for film fans, a dilemma for movie-marketing executives.

In an age of widescreen 3-D, rainbow-colored, star-driven spectacles, how do you sell a black-and-white film shot in a 2-D boxy format, with no A-listers and barely a word of spoken dialogue?

There's only one answer. Make people love it so much they do the selling for you, talking it up as one of the freshest, cleverest and sweetest nights out at the movies they've had in a while.

A throwback to the silent-film era, "The Artist" has been winning over audiences since premiering at last May's Cannes Film Festival and could become the first serious silent contender at the Academy Awards since the earliest years of the Oscars.

A couple of years ago, French writer-director Michel Hazanavicius felt utterly alone thinking that a silent movie might have a place in today's digital cinema era.

"It's something I had in mind for a long, long time, but it's very hard to find the money," Hazanavicius said at September's Toronto International Film Festival, where "The Artist" also played. "It was like a fantasy. Oh, my dream would be to produce a silent movie. And people would say, `Yeah, yeah, but in real life, what do you want to do?'"

Then came Hazanavicius' two "OSS 117" spy spoofs, both hits in France. With fresh box-office clout, he pitched his silent-movie idea to producer Thomas Langmann.

"Everybody thought I was crazy, and then I found someone more crazy than I was," Hazanavicius said. "He said, `OK, let's do it.'"

Hazanavicius recruited French star Jean Dujardin, his "OSS 117" leading man, for the title role of "The Artist," 1920s Hollywood silent-film sensation George Valentin, whose fortunes abruptly slide as the sound era takes over.

As George tumbles from the top to the bottom, rising talkies star Peppy Miller (Hazanavicius' wife, Berenice Bejo), becomes a guardian angel trying to look out for her former idol.

Shot in Los Angeles, "The Artist" grandly recreates old Hollywood and beautifully weaves from comedy to melodrama, lively action to clever dance numbers. Almost all of the scant dialogue is told the old-fashioned way ? through title cards ? but "The Artist" is far from silent. The film features a gorgeous, jazzy musical score and brilliant sound effects that pop from the speakers during otherwise hushed sequences.

While Dujardin and Bejo are relatively unknown to U.S. audiences, the supporting cast includes such Hollywood regulars as John Goodman, James Cromwell, Missi Pyle, Malcolm McDowell and Penelope Ann Miller. The film also co-stars a scene-stealing canine, Uggie, a Jack Russell terrier who is George's constant companion and co-star in his big-screen silent adventures.

"The Artist" picked up Harvey and Bob Weinstein as executive producers, whose Weinstein Co. is distributing the film domestically and aiming to do what the brothers do best ? attract Oscar attention that can make a mainstream hit out of an art house film.

"Marketing is strictly word of mouth. It's almost impossible to market, but I do think that everyone who sees it falls in love with it," said Erik Lomis, head of distribution for Weinstein. "I think it's a picture that can play everywhere, and I think it will play everywhere. It's just going to take some time to gestate in the market place."

The film already is a hit in France, where it opened in October. It debuts Friday in four New York City and Los Angeles theaters, and Weinstein will gradually roll it out to the rest of the country during the buildup to the Jan. 24 Oscar nominations.

"The Artist" has a strong shot at a best-picture nomination in a field that could include such heavy-hitters as Steven Spielberg's "War Horse," David Fincher's "The Girl With the Dragon Tattoo," George Clooney's "The Descendants" and Brad Pitt's "Moneyball."

Charles Chaplin continued making silent films into the 1930s, and other filmmakers occasionally have tried it, notably Mel Brooks with his 1976 comedy "Silent Movie." But a feature-length silent film has not competed for best picture since the late 1920s, when "Wings" and "Sunrise" took the top honors at the very first Oscars and the acting prizes went to performers in silent films, Emil Jannings and Janet Gaynor.

Even with an over-abundance of strong performances for the upcoming Oscars, "The Artist" might have acting prospects, too. Bejo's Peppy is a charming spitfire, while Dujardin won the best-actor prize at Cannes for "The Artist," a role that allowed him to emulate some of his early film heroes.

"There were lots of influences I took from, for example, Gene Kelly or someone like Douglas Fairbanks," Dujardin said. "Also, what I have to offer is very instinctual. I just let it go. ... Almost a fantasy, like imagining how would I be if I was kind of a big star, a little infatuated with myself at the end of the `20s, who's kind of extremely enthusiastic and at the same time happy. At the same time, a little naive. There's also a slight schizophrenic side to him."

"The Artist" arrives during a holiday crush of comedies, action flicks, family films and other Hollywood blockbusters that have colossal advertising budgets behind them.

Hazanavicius hopes audiences come out for his quaint little silent film, but it's now up to fans to do the talking and persuade other people to turn up.

"It's not really my problem. I made the movie I wanted to see, and now I've seen it and I'm happy with it. If people want to come, they will come. If they won't, I can't go in the house of everybody and say, `You, go to see a black-and-white silent movie!' I'm not Stalin. It's a free country," Hazanavicius said.

"I'm sure that people are scared. Everybody was scared from the very beginning. But they have to trust themselves, and they will enjoy it, if they come."

___

Online:

http://weinsteinco.com/sites/the-artistorry

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20111122/ap_en_mo/us_film_silent_movie

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Thursday, 24 November 2011

Poor recycling of BACE1 enzyme could promote Alzheimer's disease

Monday, November 21, 2011

Sluggish recycling of a protein-slicing enzyme could promote Alzheimer's disease, according to a study published online on November 21 in The Journal of Cell Biology (www.jcb.org).

Abeta, the toxic protein that accumulates in the brains of Alzheimer's patients, is formed when enzymes cut up its parental protein, known as amyloid precursor protein. One of those enzymes is beta-secretase or BACE1. BACE1 cycles between the Golgi apparatus and the plasma membrane, traveling through endosomes on the way. A protein complex called the retromer helps transport proteins back from endosomes to the Golgi. Previous studies have found reduced levels of two retromer components, including the protein VPS35, in the brains of patients with Alzheimer's disease.

To find out whether VPS35 affects Alzheimer's disease progression, Wen-Cheng Xiong and colleagues crossed two mouse lines to create animals that are prone to many symptoms of the disease and generate half the normal amount of VPS35. The mice displayed Alzheimer's-like abnormalities earlier than their parental strains, and their brains accumulated more Abeta.

Cells lacking VPS35 carried extra BACE1 in their endosomes, consistent with a defect in retromer-mediated protein transport. BACE1 is more active in the acidic interior of endosomes than in the more basic surroundings of the Golgi apparatus. Thus, by leaving more BACE1 trapped in endosomes, the decline in VPS35 levels could enhance BACE1 activity and generate more Abeta. Although no VPS35 mutations have so far turned up in Alzheimer's patients, the protein's level in the brain dwindles in aging mice. The researchers suspect that certain Alzheimer's disease risk factors, such as oxidative stress, also diminish VPS35 levels in the brain.

###

Rockefeller University Press: http://www.rupress.org/

Thanks to Rockefeller University Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/115359/Poor_recycling_of_BACE__enzyme_could_promote_Alzheimer_s_disease_

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NBC apologizes to Bachmann for Fallon song choice (AP)

ST. PAUL, Minn. ? GOP Presidential candidate Michele Bachmann received an apology from an NBC executive after an off-color song was played during her appearance on Jimmy Fallon's "Late Night," her spokeswoman said late Wednesday.

The Minnesota congresswoman received a personal letter from NBC's vice president for late night programming, Doug Vaughan, a day after she appeared on the show. As Bachmann walked onstage, the show's band had played a snippet of a 1985 Fishbone song entitled "Lyin' Ass B----."

Vaughan wrote that the incident was "not only unfortunate but also unacceptable," Bachmann spokeswoman Alice Stewart told The Associated Press. She said Vaughn offered his sincerest apologies and said the band had been "severely reprimanded."

Fallon also apologized to Bachmann when they spoke earlier Wednesday, she said. He'd tweeted earlier, saying he was "so sorry about the intro mess."

"He was extremely nice and friendly and offered his apology, and she accepted it," Stewart said, adding that the comedian said he was unaware the band planned to play the song. "It's just unfortunate that someone had to do something so disrespectful."

Bachmann lashed out earlier Wednesday at NBC for not apologizing or taking immediate disciplinary action. In her first comments on the flap, Bachmann said on the Fox News Channel that the Fallon show band displayed sexism and bias by playing the song.

"This is clearly a form of bias on the part of the Hollywood entertainment elite," Bachmann said. She added, "This wouldn't be tolerated if this was Michelle Obama. It shouldn't be tolerated if it's a conservative woman either."

She went further on a national radio conservative radio show hosted by Michael Medved, calling the incident "inappropriate, outrageous and disrespectful."

On Fox, Bachmann expressed surprise that she's heard nothing from the TV network. She suggested that discipline for the show's band, The Roots, was in order. She said she believed Fallon's comments to be sincere.

One of Bachmann's congressional colleagues, New York Democrat Nita Lowey, had called on NBC to apologize for its "insulting and inappropriate" treatment of its guest.

An NBC spokeswoman didn't return a phone message from The Associated Press.

The Roots' bandleader, Ahmir "Questlove" Thompson, has said the song was a "tongue-in-cheek and spur-of-the-moment decision."

Bachmann, who is lagging in presidential polls, has spent the week promoting her new autobiography in national television interviews.

___

AP Television Writer David Bauder in New York and Associated Press writer Erin Gartner in Chicago contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/celebrity/*http%3A//news.yahoo.com/s/ap/20111124/ap_en_mu/us_bachmann_song_choice

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Wednesday, 23 November 2011

PIC: Emma Stone and Andrew Garfield Hold Hands in New York City (omg!)

PIC: Emma Stone and Andrew Garfield Hold Hands in New York City

Emma Stone and Andrew Garfield are madly in love -- and they don't care who knows it!

The Amazing Spider-Man costars -- who have been dating since the spring -- walked hand-in-hand through New York City's East Village on Sunday, marking the first time the couple has shown affection in public. See more pictures of the couple on Just Jared.

PHOTOS: Emma Stone's style evolution

(Though Garfield has attended a handful of events with Stone in the past week, the couple refuses to be photographed together on the red carpet.)

PHOTOS: Stars who fell in love on set

On Saturday, the pair was even seen buying jelly donuts and kissing each other at the Donut Pub, a source tells Us Weekly.

What makes Garfield, 28, such a perfect match for Stone, 23?

PHOTOS: Stars as superheroes

"Andrew is one of the most giving actors I've ever worked with," The Help star told Teen Vogue in September. "If I needed to get to a place of love or sadness in a scene, he'd leave messages on my phone to replay, or slip in lines off camera for a different reaction than what was scripted. He gave me so much to react to."

Get more Us! Follow us on Twitter, Friend us on Facebook, Subscribe to Us Weekly

Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//us.rd.yahoo.com/dailynews/external/omg_rss/rss_omg_en/news_pic_emma_stone_andrew_garfield_hold_hands_york153015648/43671218/*http%3A//omg.yahoo.com/news/pic-emma-stone-andrew-garfield-hold-hands-york-153015648.html

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Five Favorite Films with Kermit the Frog (and Miss Piggy Too!)

Kermit the Frog and Miss Piggy have been big movie stars for many years, and now they're back with The Muppets, which opens in theaters this week. In their latest big screen adventure, Kermit and Piggy are joined by Muppet superfan Walter, as well as non-Muppets Gary (Jason Segel) and Mary (Amy Adams), who help to get the whole gang back together for a wild televised variety show that may help them to save their old Muppet Theater from the wrecking ball. In interviews with Rotten Tomatoes, Kermit (performed by Steve Whitmire) and Miss Piggy (performed by Eric Jacobson) shared a few of their favorite films (spoiler: Miss Piggy prefers her own movies), and also talked about their craziest fans and their longevity in the movie business. Without further ado, let's begin with Kermit the Frog's Five Favorite Films:


Kermit the Frog: Wow, do I have five favorite films? Well, I love The Wizard of Oz because of the rainbow; it's kind of an inspiration for me. That's a good one.

Quite frankly, I really like The Rocky Horror Picture Show. It's one of my favorites.

What do you like about that one?

Well, Tim Curry. And I'm sorry he got so typecast in that because he's got such a broad range, but we worked with Tim in Muppet Treasure Island, and we actually sung some of those songs in between takes. Even in this movie we were singing them with Jason [Segel] and Amy [Adams].

Five films, wow. What else? I love Vanilla Sky.

You do?

I love it. It's so weird. It's like what happens to me when I sit on a log and stare at the water too long. I love that one. I'm giving you strange answers, aren't I?

No, no, this is great. You watch a lot of movies, then.

I do. I do, whenever I can.

Ooh, I thought of one! The Devil's Advocate.

Really...

The morals... I love that. I love that movie. That's one of my other favorites. Al Pacino, he's done a lot of stuff, but I think that's his best role. I love it.

I hesitate to say Deliverance, but I must say I like the banjo, so why don't we go with that? It was shot down in the swamp, where I'm from, and I think there's a pig scene, too, so there you go. We're all set.

Next, Kermit talks about working with Fozzie, his craziest fans, and how his family first got into show business.

Source: http://www.rottentomatoes.com/m/1923979/news/1923979/

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Tuesday, 22 November 2011

49 penguins freed after rescue from NZ oil spill (AP)

WELLINGTON, New Zealand ? Forty-nine penguins rescued from an oil spill off New Zealand have been set free after being cleaned and nursed back to health by wildlife officials.

The birds released Tuesday are among 343 little blue penguins that have been cleaned of oil since a cargo ship ran aground on a reef near Tauranga on Oct. 5 and spilled some 400 tons of fuel oil.

More than 2,000 sea birds died in the spill.

The penguins were nursed back to health at a wildlife facility manned by specialists from New Zealand, Australia and the United States. They were fitted with microchips so they can be monitored after their release.

Wildlife Response Manager Kerri Morgan says it's important that wild penguins do not remain in captivity for too long because they can develop injuries and illnesses.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111122/ap_on_re_as/as_new_zealand_penguins_released

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Monday, 21 November 2011

CrunchBase Reveals: The Largest Seed And Angel Fundings From The Past Thirty Days

Screen Shot 2011-11-21 at 1.25.55 PMAs many of you already know, CrunchBase is a big, free resource for anyone trying to get the latest information on hot new startups, or competitors to their own hot new startups, the investing focus of various investors, and much more. The thing is, CrunchBase isn't used all that much on TechCrunch itself beyond the widgets you see at the end of articles. So, I'm going to start testing out a variety of posts with the goal of surfacing new and interesting information for all of you. To kick things off, I'll take a brief look at the largest seed and angel funding rounds that we recorded over the last 30 days -- you'll see just how big some of these rounds have been getting. But before I get into that, though, here are a few thoughts on using CrunchBase on TechCrunch.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Sz5YVLROF_w/

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